Arsenal have hit a rich vein of form since their 2-0 defeat by Aston Villa last month, but are competing against a City side who are now unbeaten in 31 games in all competitions.
The Gunners have a chance at least to apply some pressure by beating Bournemouth in the early kick-off at the Emirates on Saturday.
Bournemouth have registered their highest-ever points tally in a Premier League season to climb to 10th spot but have only beaten Arsenal once before.
City were not at their best against Nottingham Forest last weekend but still found a way to win and are strong favourites to wrap up an unprecedented fourth straight English title.
Arsenal will cling to the hope that Wolves can complete a rare double against City after they won 2-1 at home earlier this season.
Guardiola, for his part, does not believe his side can afford to drop any points in the run-in.
“With four games left, it’s like climbing a mountain,” he said. “They are very tough games… If we draw a game, we are not going to win the Premier League. It is what it is.”
© Agence France-Presse
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