Lionel Messi proved to be Argentina’s saviour as his stunning hat-trick secured a 3-1 victory over Ecuador and World Cup qualification for Russia 2018.
Meanwhile, a Gabriel Jesus brace and Paulinho goal saw Brazil to a deserved 3-0 win over Chile, who will miss the 2018 World Cup.
Uruguay secured second place in South American qualifying and a spot at the 2018 World Cup with a dominant display against Bolivia.
The United States failed to qualify for the World Cup after suffering a shock 2-1 loss to Trinidad and Tobago as rivals Panama and Honduras both won in Concacaf.
Honduras will face Australia in a play-off to reach the 2018 World Cup after a stunning 3-2 win over Mexico in qualifying on Tuesday.
Here are the highlights from these respective matches:
Watch: Ecuador vs Argentina
Watch: Brazil vs Chile
Watch: Uruguay vs Bolivia
Watch: Honduras vs Mexico
Watch: Trinidad and Tobago vs USA