Former Caf Champions League winners Mamelodi Sundowns face the prospect of elimination as they languish in last place in Group C after succumbing to a 1-0 loss against AS Togo-Port.
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Egyptian champions Al Ahly got their Caf Champions League campaign up and running with a 3-0 win over Township Rollers but ES Tunis remained in charge of Group A in dramatic circumstances.
Hossam El Badry’s side welcomed back their Egypt internationals from a disappointing World Cup campaign and claimed a first win of the round-robin stage at the third time of asking thanks to goals from Walid Azarou and substitute Islam Mohareb either side of a 73rd-minute penalty from Tunisia defender Ali Maaloul.
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ES Tunis were stunned to find themselves 2-0 down midway through the first half at home to KCCA.
Jackson Nunda opened the scoring after 19 minutes for the Ugandan side before Khalil Chemmam scored an own goal.
Goals in quick succession either side of the half-hour mark from Anice Badri and Saad Bguir restored parity, leaving Bilel Mejri to score a late winner and move ES Tunis on to seven points, three clear of Al Ahly.
MC Alger made TP Mazembe work to maintain their 100% record in Group B but Elia Meschak struck two minutes from time for the five-time African champions.
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ES Setif saw off Difaa El Jadida 2-1 – with Houssam Ghacha the supplier of a late twist in that game – in the section’s other encounter, with TP Mazembe five points clear of their match-day three opponents at the summit.
Horoya and Wydad Casablanca remain locked together on five points in the qualification places in Group C after their match finished 1-1.
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The reigning champions from Morocco led through Ismail El Haddad but their Guinean hosts hit back thanks to Ocansey Mandela.
Pitso Mosimane’s side looked a shadow of their former selves without the presence of star attacking duo Khama Billiat and Percy Tau.
A poor offensive showing coupled with a defensive mishap saw Togo-Port secure a historic victory against Masandawana after Abel Hunlede sprung the off-side trap to score the only goal of the game.
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Etoile du Sahel opened up a lead in Group D after storming to a 3-0 win at Mbabane Swallows, while Zesco United and Primeiro de Agosto shared a goalless draw in Zambia.
The eight-time South African league champions will have their work cut out for them, as they need to secure victory in the return clash in Tshwane less than two weeks from now, while hoping that Horoya and Wydad Athletic play to a stalemate in their clash.