Manchester City will face Lyon or Juventus in the one-legged Champions League quarter-final in Lisbon if they can overcome Real Madrid in the last-16.
Madrid trail Manchester City in their unfinished round of 16 tie, while Juventus trail Lyon 1-0 ahead of the second leg.
Bayern Munich look likely to face either Barcelona or Napoli as they hold a commanding 3-0 lead over Chelsea, while debutants Atalanta will face Paris Saint-Germain.
Meanwhile, RB Leipzig will play Atletico Madrid after both teams knocked out Premier League opposition in the last 16.
With the route through the tournament drawn all the way to the final, fans can also look forward to some potentially huge clashes in the final four.
Madrid could face Barcelona in a Clasico semi-final, with Pep Guardiola also potentially up against one of his former sides in Barca or Bayern if Man City go through.
Champions League quarter-final draw:
QF1: Real Madrid or Manchester City vs Lyon or Juventus
QF2: RB Leipzig vs Atletico Madrid
QF3: Napoli or Barcelona vs Chelsea or Bayern Munich
QF4: Atalanta vs Paris Saint-Germain
Champions League semi-final draw:
SF1: Winner QF1 vs Winner QF3
SF2: Winner QF2 vs Winner QF4
Champions League final:
Winner SF2 vs Winner SF1
The quarter-finals, semi-finals and final will all be played as a straight one-leg knockout tournament in Lisbon throughout August.
Games will be split between Benfica’s Estadio do Sport Lisboa e Benfica and Sporting Lisbon’s Estadio Jose Alvalade.
The remaining last-16 second leg ties will be concluded over August 7-8, before the quarter-finals are played over four days in Portugal, beginning August 12.
The semi-finals will take place on August 18-19, with the final at Benfica’s stadium on August 23.
Atalanta, Atletico, Leipzig and PSG are all already qualified for the quarter-finals having knocked out Valencia, Liverpool, Tottenham and Borussia Dortmund respectively.
Uefa confirmed on Thursday that the remaining last-16 second leg matches will be played at home grounds as previously scheduled.
Manchester City will host Real Madrid while Chelsea will travel to Bayern Munich, among the four last-16 fixtures still to be played.
There are still six-second legs to be played in the Europa League, with two ties to be played as one-off fixtures after the first legs were cancelled.